Medicinal preparation



Patented June 25, 1935 I MEDICINAL PREPARATION Fritz Lange and Ludwig Taub, Wuppertal-ElberfeldQGermany, assignors to Winthrop Chemical Company, Inc., New York, N. Y., a corporation of New York No Drawing. Application October 1, 1930, Serial No. 487,087. In Germany October 9, 1929 7 Claims. (Cl. 167-81) The present invention relates to new medicinal molysis of pressed brewer's yeast with the same preparations comprising a liquid containing vitaquantity of cane-sugar, separating the insoluble mine 13, cell walls and carefully concentrating the liquid Preparations containing vitamine B are known obtained up to a sugar content of about 75%,

in the art, for example in form of extracts of 600 parts by weight of water are added, and the 5 yeast. Object of our present invention is the mixture is fermented at about 30 C. after inocprovision of a medicinal preparation containing ulating in the customary manner with a pure vitamine B in form of a palatable beverage, culture of a strongly fermenting south wine yeast.

In accordance with our invention such a bev- As soon as the evolution of carbon dioxide is com- 10 erage containing vitamine B'is produced by ferplete which is the case after about 2-3 weeks, 10 mentation of an extract containing vitamine B the fermented solution is with advantage situated with the addition of fermentable types of sugars. in a cool place and the clear liquid which has It is a surprising fact that according to the bioa south wine like taste and coloration, is seplogical tests after such a fermentation process arated from the yeast. It appears established by the vitamine B present in the starting material animal experiments in the customary manner is maintained unimpaired and in undiminished that the vitamine B effect of the fermented strength, since it appears from the literature that product corresponds qualitatively and q the same vitamine B which, for example, is obtatively to that of the starting material. tained from rice polishings, is destroyed by fer- We claim:

mentation (compare Biochemical Journal vol. 22, l. Medicinal preparations comprising a liquid 20 p, 1362 and seq.) containing vitamine B, prepared by fermentation As starting materials containing vitamine B, of a yeast extract containing a fermentable for example, extracts or concentrates obtainsugar by means of a strongly fermenting yeast able in the customary manner by autolysis of at a temperature between about l5-30 C., said yeast or by extraction of yeast have proved useliquids being clear solutions of south wine colora- 25 ful. Preferably we start with a product which is tion, being palatable, therapeutically valuable obtained by first subjecting yeast to plasmolysis tonics and restoratives. by addition of a fermentable sugan for example, 2. Medicinal preparations comprising a. liquid cane-, malt-, fruitor grape-sugar, then separatcontaining vitamine B, prepared by fermentation ing the insoluble cell walls from the liquid proof a yeast plasmolysate by means of a strongly 30 duced and carefully concentrating the plasfermenting yeast at a temperature between about molysate, for example, in such a degree that an 15-30 C., which yeast plasmolysate has. been obextract containing 75% of sugar is obtained. The tained by plasmolyzing yeast in admixture with fermentation of such a concentrate can be efafermentable sugar, said liquids being clear solufected by any, preferably strongly fermenting tions of south wine coloration, being palatable, 35

yeast, the kind of yeast depending on the aroma therapeutically valuable tonics and restoratives. which is desired to be obtained in the product of 3. Medicinal preparations comprising a liquid manufacture. We prefer to employ a wine yeast, containing vitamine B, prepared by fermentation especially a south wine yeast such as sherry, of a yeast plasmolysate by means of a strongly portwine-, malaga-, or Tokay-yeast or the like. fermenting yeast at a temperature between about The fermenting process is effected at a tempera- 15-30 C., which yeast plasmolysate has been obture between about l5-30 C., preferably at 30 tained by plasmolyzing yeast in admixture with C. and is finished when the formation of carbonic cane sugar, said liquids being clear solutions of acid has stopped. In general, for the fermentasouth wine coloration, being palatable, therapeution, a period of 2-3 weeks is required. The fertically valuable tonics and restoratives. 45 mented product is after separating insoluble mai;- 4. Medicinal preparations comprising a. liquid ter a clear liquid of south wine coloration and containing vitamine B, prepared by fermentation wine like taste and provides by. its appetizing efof a yeast plasmolysate by means of a strongly ficacy a palatable tonic and restorative of high fermenting south wine yeast at a temperature therapeutical value which of course can be mixed between about l5-30 C., which yeast plasmolysate with other suitable medicinal preparations. has been obtained by plasmolyzing yeast in ad- Our invention is illustrated by the following ex mixture with cane sugar, said liquids being clear ample without being limited thereto: solutions of south wine coloration, being palatable,

To 400 parts by weight of a yeast extract contherapeutically valuable tonics and restoratives. 5 taining vitamine B which is prepared by plas- 5. Medicinal preparations comprising a liquid containing vitamine B, prepared by fermentation of a yeast plasmolysate by means of a south wine yeast of the group consisting of sherry-, portwine-, and Tokay-yeast at a temperature between about 15-30 C., which yeast plasmolysate has been obtained by plasmolyzing yeast in admixture with cane sugar, said liquids being clear solutions of south wine coloration, being palatable, therapeutically valuable tonics and restoratives.

6. Medicinal preparations comprising a liquid containing vitamine B, prepared by fermentation of a mixture of 400 parts by weight of a yeast plasmolysate containing 75% of cane-sugar, and 600 parts by weight of water by means of a south wine yeast of the group consisting of sherry, portwineand Tokay-yeast at a temperature between about 15-30 C., which yeast plasmolysate has been obtained by plasmolyzing yeast in admixture with cane sugar, said liquids being clear solutions of south wine coloration, being palatable, therapeutically valuable tonics and restoratives. 7. Medicinal preparations comprising a liquid containing vitamine B, prepared by fermentation of a mixture of 400 parts by weight of a yeast plasmolysate containing 75% of cane-sugar and 600 parts by weight of water by means of a south wine yeast of the group consisting of sherry-, portwineand Tokay-yeast at a temperature of about 30 C. during 2-3 weeks, which yeast plasmolysate has been obtained by plasmolyzing yeast in admixture with cane sugar, said liquids being clear solutions of south wine coloration, being palatable, therapeutically valuable tonics and restoratives.

FRITZ LANGE. LUDWIG TAUB. 

